Genital Tract Mucosal Immunity In Rwanda Women (Exposed Seronegative)
This cohort will in part be recruited in part from the existing Rwanda women inter association study assessment cohort which began with 715 HIV seropositive women and 221 seronegative women
Existing Seronegative RWISA participants
Of the seronegative women, ~30 reported current commercial sex work (CSW) at a RWISA visit. Additionally, 9 -15 women have reported an HIV-positive partner at one of the RWISA visit. We are requesting use of existing banked plasma and cervicovaginal lavage fluid from these women from visits where they reported the high-risk behavior. In addition, for women who continue high-risk behavior, we will approach them for consent to participate in enhanced sampling during their RWISA visits, as per the protocol described in the appendix.
Existing Seropositive RWISA participants
We will request existing specimens for 20 seropositive RWISA participants. In addition, we will approach 48 HIV-infected RWISA participants over the 5 years of the study for enhanced sampling. New Recruitment: Potential participants will be approached at their RWISA visits, through male HIV-infected clients or when receiving gynecologic service at the Nyacyonga health center in Kigali. They will be screened to see if they meet the inclusion criteria below.